Internal Publications
Rational identification of an optimal antibody mixture for targeting the epidermal growth factor receptor.
Koefoed K, Steinaa L, Søderberg JN, Kjær I, Jacobsen HJ, Meijer PJ, Haurum J, Jensen A, Kragh M, Andersen PS, Pedersen MW
Landes Bioscience, Nov/Dec, 2011.
Limits for antibody affinity maturation and repertoire diversification in hypervaccinated humans.
Poulsen TR, Jensen A, Haurum JS, Andersen PS
J Immunol., October, 2011.
Preclinical pharmacokinetics and safety of Sym004: A synergistic antibody mixture directed against epidermal growth factor receptor.
Skartved NJ, Jacobsen HJ, Pedersen MW, Jensen PF, Sen JW, Hey A, Kragh M.
Clin Cancer Res., August, 2011.
Consistent manufacturing and quality control of a highly complex recombinant polyclonal antibody product for human therapeutic use
Frandsen TP, Naested H, Rasmussen SK, Hauptig P, Wiberg FC, Rasmussen LK, Jensen AM, Persson P, Wikén M, Engström A, Jiang Y, Thorpe SJ, Förberg C, Tolstrup AB.
Biotechnol Bioeng., April, 2011.
Capturing the Natural Diversity of the Human Antibody Response against Vaccinia Virus
Lantto J, Hansen MH, Rasmussen SK, Steinaa L, Poulsen TR, Duggan J, Dennis M, Naylor I, Easterbrook L, Bregenholt S, Haurum J, Jensen A.
J.Virology, February, 2011.
Development of Mass Spectrometry Based Techniques for the Identification and Determination of Compositional Variability in Recombinant Polyclonal Antibody Products
Persson P, Rasmussen LK, Holmberg E, Frandsen TP. Anal.Chem., 2010, 82, 7272-7282.
Single-Batch Production of Recombinant Human Polyclonal Antibodies
Nielsen LS, Baer A, Müller C, Gregersen K, Moenster NT, Rasmussen SK, Weilguny D, Tolstrup AB.
Mol Biotechnol, 2010, 45:3, 257-266.
Sym004: A Novel Synergistic Anti–Epidermal Growth Factor Receptor Antibody Mixture with Superior Anticancer Efficacy
Pedersen MW, Jacobsen HJ, Koefoed K, Hey A, Pyke C, Haurum JS and Kragh M.
Cancer Research 70, 588, January 15, 2010.
Poulsen TR, Meijer PJ, Jensen A, Nielsen LS, Andersen PS.
J Immunol. 2007 Sep 15;179(6):3841-50.
Expert Opin Biol Ther. 2006 Sep;6(9):905-12. Review.
Haurum JS
Drug Discov Today. 2006 Jul;11(13-14):655-660.
Allergen-specific polyclonal antibodies reduce allergic disease in a mouse model of allergic asthma
Moerch U, Haahr Hansen M, Vest Hansen NJ, Rasmussen LK, Oleksiewicz MB, Frandsen TP, Haurum JS, Bregenholt S.
Int Arch Allergy Immunol. 2006;140(3):261-269.
Production of target-specific recombinant human polyclonal antibodies in mammalian cells
Wiberg FC, Rasmussen SK, Frandsen TP, Rasmussen LK, Tengbjerg K, Coljee VW, Sharon J, Yang CY, Bregenholt S, Nielsen LS, Haurum JS, Tolstrup AB.
Biotechnol Bioeng. 2006 Jun 5;94(2):396-405.
Isolation of human antibody repertoires with preservation of the natural heavy and light chain pairing
Meijer PJ, Andersen PS, Haahr Hansen M, Steinaa L, Jensen A, Lantto J, Oleksiewicz MB, Tengbjerg K, Poulsen TR, Coljee VW, Bregenholt S, Haurum JS, Nielsen LS.
J Mol Biol. 2006 May 5;358(3):764-72. Epub 2006 Mar 2.
Protein Expression and Purification, 2005; 41:373-377.
IDrugs. 2005 May;8(5):404-9. Review.
External Publications
Passive immunotherapies protect WRvFire and IHD-J-Luc vaccinia virus infected mice from lethality by reducing viral loads in the upper respiratory tract and internal organs.
Marina Zaitseva, Senta M. Kapnick, Clement A. Meseda, Elizabeth Shotwell, Lisa R. King, Jody Manischewitz, John Scott, Shantha Kodihalli, Michael Merchlinsky, Henriette Nielsen, Johan Lantto, Jerry P. Weir, and Hana Golding
J. Virol., 2011, doi:10.1128/JVI.00121-11
Rozrolimupab, symphobodies against rhesus D, for the potential prevention of hemolytic disease of the newborn and the treatment of idiopathic thrombocytopenic purpura.
Stasi R.
Curr Opin Mol Ther. 2010 Dec;12(6):734-40.
Symphogen internalized EGFR
Hansen, S.
www.BioCentury.com, 2010 January 25; A5-A6.
Symphogen, Origen develop antibody-producing chickens
Carroll, J.
www.fiercebiotech.com, 2009 March 6.
Chen L, Liebman MA, Teodorescu-Frumosu S, Schnitzler AC, Sharon J.
Immunol Lett. 2003 Aug 5;88(2):135-140.
Methods Mol Biol. 2002;178:101-112. Review.
Recombinant polyclonal antibody libraries
Sharon J, Sarantopoulos S, Den W, Kao CY, Baecher-Allan CM, Santora KE, Sompuram SR, Petersen-Mahrt S, Williams BR.
Comb Chem High Throughput Screen. 2000 Jun;3(3):185-196. Review.
Santora KE, Sarantopoulos S, Den W, Petersen-Mahrt S, Sompuram SR, Sharon J.
Comb Chem High Throughput Screen. 2000 Feb;3(1):51-57.
J Immunol Methods. 1999 Jan 1;222(1-2):45-57.
